Therapeutic Inhaled Essential Oils (TIEO) for the Clinical Setting

Presented by Soothing Scents, Inc. Makers of QueaseEASE

Wendy S. Nichols, APRN, BSN, CRNA
[email protected] // 1 -888-393-7330

Nell L. Tharpe, RN, CNM, MS, FACNM
[email protected] // 1-888-393-7330


Course Delivery: Web-Based

Target Participants: Registered Nurses

Expiration: 3 Years from date of successful completion

Course Overview:

As the saying goes, what is old is new again, and nothing could be truer for essential oil therapy. For several thousand years, in many places on earth, plant-based therapies had a leading role in health and wellbeing, but with the advent of conventional medical technology and chemically derived drugs, natural remedies such as essential oils were left behind.

Fortunately, the balance is returning. Conventional healthcare has once again rediscovered the benefits of natural healing modalities. One such method, the use of inhaled essential oil vapor, is being increasingly implemented in hospitals, surgery centers, hospices and chemotherapy centers as a safe, effective method for managing nausea and anxiety.

Therapeutic inhaled essential oil therapy, or TIEO (pronounced Tie-Oh), is a designated independent nursing intervention that not only decreases patient discomfort; it also increases satisfaction with their care.

The purpose of this course is to provide registered nurses with current, evidence-based knowledge, clinical skills, and professional accountability standards, to safely and confidently utilize TIEO therapy with their patients. Upon successful completion, course participants will obtain documentation from an ANCC –accredited skill competency course, validating their knowledge, proficiency and safety with the use of therapeutic inhaled essential oils in the clinical setting.

ss-course-1Soothing Scents Inc. is the maker of QueaseEASE, an essential oil blend, created for use in hospitals, clinics and surgery centers.

Developed by a nurse anesthetist searching for a rapid, self- administered remedy for post-operative nausea, QueaseEASE combines a science-driven essential oil blend with a specially designed delivery system, possessing the safety and precision required for patient use.

Because there are no other products currently available for use in the clinical area that meet these important safety standards, this presentation will focus exclusively on the use of QueaseEASE.

ANCC did not endorse any product, or receive any commercial support or sponsorship for this course.


    1. Medicinal and Other Uses of North American Plants. New York. Dover Publications 1979.
    2. Chemical Technology in Antiquity. ACS Symposium Series, chapter 8, pp 219-244 Vol. 1211 Nov 20, 2015 (3)Unschuld Paul U., Medicine in China: A History of Pharmaceutics, University of California Press, Berkeley, CA. 1986 (4)Meulenbeld, G. J. A History of Indian Medical Literature(Groningen 2002), vol. IA, pp. 7-180.
    3. Rosenbaum, Lisa. “Understanding bias—the case for careful study.” New England Journal of Medicine 372.20 (2015): 1959-1963.
    4. Light, Donald W. and Lexchin, Joel and Darrow, Jonathan J., Institutional Corruption of Pharmaceuticals and the Myth of Safe and Effective Drugs (June 1, 2013). Journal of Law, Medicine and Ethics, 2013, Vol. 14, No. 3: 590-610
    5. Nahin, R et al., Expenditures on complementary Health Approaches: United States, 2012. National Health Statistics reports. Number 95, June 22, 2016.
    6. Beck, Charles. An Introduction to Plant Structure and Development: Plant Anatomy for the twenty-First Century, 2nd Edition. Cambridge University Press UK 2010
    7. Benson HA, Sarveiya V, Risk S, Roberts MS. Influence of anatomical site and topical formulation on skin penetration of sunscreens. Therapeutics and Clinical Risk Management. 2005;1(3):209-218.
    8. Araneda, Ricardo C., Abhay D. Kini, and Stuart Firestein. “The molecular receptive range of an odorant receptor.”

Nature neuroscience 3.12 (2000): 1248-1255.

  1. Larsson, M. (2005). Smell your way back to childhood: Autobiographical odor memory. In W. Ostreng (Ed.) Synergies: Interdisciplinary Communications 2003/2004, pp. 86-89. Centre for Advanced Study.
  2. Herz, Rachel, “Ah, Sweet Skunk, why we like or dislike what we smell”. The Dana Foundation, Cerebrum. Oct 1, 2001
  3. Cotton, J “A comparative analysis of isopropyl alcohol and ondansetron on the treatmet of post operative nausea and vomiting from the hospital setting to home.” AANA J. 2007 Feb:75(1):21-6.
  4. Inderscience Publishers. “Scents sell: The sweet smell of success.” ScienceDaily. ScienceDaily, 9 September 2015.
  5. McDonnell, John. “Music, scent and time preferences for waiting lines.” International Journal of Bank Marketing 25.4 (2007): 223-237.
  6. QueaseEASE study Booklet. Thirteen investigational reviews of QueaseEASE in clinical use, Soothing Scents, Inc. 2015.
  7. Valentina Parma, Stefania FerraroStacie S. MillerFredrik ÅhsJohan N. Lundström. “Enhancement of Odor Sensitivity Following Repeated Odor and Visual Fear Conditioning.” Chemical Senses 40.7 (2015).
  8. Herrstedt, J. (2004). Risk -benefit of anti-emetics in prevention and treatment of chemotherapy – induced nausea and vomiting. Expert Opin Drug Saf. 3 (3): 231-48.
  9. Thomas-Danguin, Thierry, Charlotte Sinding, Sébastien Romagny, Fouzia El Mountassir, Boriana Atanasova, Elodie Le Berre, Anne-Marie Le Bon, and Gérard Coureaud. “The perception of odor objects in everyday life: a review on the processing of odor mixtures.” Frontiers in Psychology 5 (2014).
  10. Hillert, Lena, Vildana Musabasic, Hans Berglund, Carolina Ciumas, and Ivanka Savic. “Odor processing in multiple chemical sensitivity.” Human Brain Mapping 28.3 (2007): 172-182.
  11. Hoffmann, Jan, and Ana Recober. “Migraine and Triggers: Post Hoc Ergo Propter Hoc?.” Current Pain and Headache Reports 17.10 (2013): 1-7.
  12. Pakalnis, Ann. “Migraine and Hormones.” Seminars In Pediatric Neurology 23.1 (2016): 92-94.
  13. Haghighi, Afshin Borhani. “Therapeutic potentials of menthol in migraine headache: Possible mechanisms of action.” Medical Hypotheses 69.2 (2007).
  14. Sasannejad, Payam, et al. “Lavender essential oil in the treatment of migraine headache: a placebo-controlled clinical trial.” European neurology 67.5 (2012): 288-291.
  15. Essential Oil Safety: A guide for Health Care Professionals. 2nd edition Robert Tisserand, Rodney Young, PhD. Churchill Livingston 2014
  16. Clinical Aromatherapy: Essential Oils in Healthcare. 3rd edition Jane Buckle, PhD, RN London, UK 2015. (27)Butcher, Howard K., et al. Nursing interventions classification (NIC). Elsevier Health Sciences, 2013.
  17. Kovac, Anthony L., Thomas A. O’Connor, Michael H. Pearman, Lance J. Kekoler, Donald Edmondson, Verna L. Baughman, John J. Angel, Christina Campbell, Holly G. Jense, Melinda Mingus, Mohammad B.G. Shahvari, and Mary R. Creed. “Efficacy of repeat intravenous dosing of ondansetron in controlling postoperative nausea and vomiting: a randomized, double-blind, placebo-controlled multicenter trial.” Journal of Clinical Anesthesia 11.6 (1999): 453-459.
  18. QueaseEASE study Booklet. Thirteen investigational reviews of QueaseEASE in clinical use, Soothing Scents, Inc. 2015.
  19. Mattila K, Toivonen J, Janhunen L, Rosenberg PH, Hynynen M. Postdischarge symptoms after ambulatory surgery: first-week incidence, intensity, and risk factors. Anesth Analg.  2005;101(6):1643–50.
  20. Penuelas, Angelica, Kimihito Tashima, Shizuko Tsuchiya, Kenjiro Matsumoto, Tomonori Nakamura, Syunji Horie, and Shingo Yano. “Contractile effect of TRPA1 receptor agonists in the isolated mouse intestine.” European Journal of Pharmacology 576.1 (2007): 143-150.
  21. Amato, Antonella, Rosa Serio, and Flavia Mulè. “Involvement of cholinergic nicotinic receptors in the menthol- induced gastric relaxation.” European Journal of Pharmacology 745 (2014): 129-134.
  22. Tate, Sylvina. “Peppermint oil: a treatment for postoperative nausea.” Journal of Advanced Nursing 26.3 (1997).
  23. Kenia, Priti, Tom Houghton, and Caroline Beardsmore. “Does inhaling menthol affect nasal patency or cough?.” Pediatric Pulmonology 43.6 (2008): 532-537.
  24. Nichols,W, Experience With Therapeutic Inhaled Essential Oil Use in Surgical C-Section Deliveries.2015, unpublished article.
  25. Silva, Camila M. S., Carlos W. S. Wanderley, Francisco J. B. Lima-Junior, Damião P. Sousa, Julianeli T. Lima, Pedro J. C. Magalhães, Armênio A. Santos, and Raimundo C. Palheta-Junior. “Carvone ( R )-(-) and ( S )-(+) enantiomers inhibits upper gastrointestinal motility in mice.” Flavour and Fragrance Journal 30.6 (2015): 439-444.
  26. Souza, Fábia Valéria M., et al. “(−)-Carvone: Antispasmodic effect and mode of action.” Fitoterapia 85 (2013): 20-24.
  27. Tayarani-Najaran, Z, E Talasaz-Firoozi, R Nasiri, N Jalali, and MK Hassanzadeh. “Antiemetic activity of volatile oil from Mentha spicata and Mentha × piperita in chemotherapy-induced nausea and vomiting.” ecancermedicalscience 7 (2013).
  28. Rahmani, Arshad H, Fahad M Al shabrmi, and Salah M Aly. “Active Ingredients of Ginger as Potential Candidates in the Prevention and Treatment of Diseases via Modulation of Biological Activities.” International Journal of Physiology, Pathophysiology and Pharmacology 6.2 (2014): 125–136. Print.
  29. Geiger, James L “The essential oil of ginger, Zingiber Officinale, and anaesthesia”, International Journal of Aromatherapy Vol 15 issue 1, p 1-14
  30. Reagan S, Kind L, Clements F. QueaseEASE Aromatherapy for Treatment of PONV. American Association of Critical Care Nurses:2009.
  31. Chrubasik, S., M.H. Pittler, and B.D. Roufogalis. “Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles.” Phytomedicine 12.9 (2005): 684-701.
  32. Salihah, Noor, Nik Mazlan, and Pei Lin Lua. “The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting.” Focus on Alternative and Complementary Therapies An Evidence-Based Approach 21.1 (2016): 8-16.
  33. Viljoen, Estelle et al. “A Systematic Review and Meta-Analysis of the Effect and Safety of Ginger in the Treatment of Pregnancy-Associated Nausea and Vomiting.” Nutrition Journal 13 (2014): 20. PMC. Web. 12 July 2016.
  34. Chioca, Lea R., et al. “Anxiolytic-like effect of lavender essential oil inhalation in mice: Participation of serotonergic but not GABA A/benzodiazepine neurotransmission.” Journal of ethnopharmacology 147.2 (2013): 412-418.
  35. Buchbauer, Gerhard, Leopold Jirovetz, and Walter Jäger. “Aromatherapy: evidence for sedative effects of the essential oil of lavender after inhalation.”Zeitschrift für Naturforschung C 46.11-12 (1991): 1067-1072.
  36. MPham, Winai Sayorwan, and Vorasith Siripornpanich. “The effects of lavender oil inhalation on emotional states, autonomic nervous system, and brain electrical activity.” J Med Assoc Thai 95.4 (2012): 598-606.
  37. Moss, Mark, et al. “Modulation of cognitive performance and mood by aromas of peppermint and ylang-ylang.” International Journal of Neuroscience 118.1 (2008): 59-77.
  38. Hongratanaworakit, Tapanee, and Gerhard Buchbauer. “Relaxing effect of ylang ylang oil on humans after transdermal absorption.” Phytotherapy Research 20.9 (2006): 758-763.
  39. Hwang, Jin Hee. “[The effects of the inhalation method using essential oils on blood pressure and stress responses of clients with essential hypertension].” Taehan Kanho Hakhoe Chi 36.7 (2006): 1123-1134.
  40. Saiyudthong, Somrudee, and Charles A. Marsden. “Acute effects of bergamot oil on anxiety-related behaviour and corticosterone level in rats.” Phytotherapy Research 25.6 (2011): 858-862.
  41. Ni, Cheng-Hua et al. “The Anxiolytic Effect of Aromatherapy on Patients Awaiting Ambulatory Surgery: A Randomized Controlled Trial.” Evidence-based Complementary and Alternative Medicine : eCAM 2013 (2013): 927419. PMC. Web. 12 July 2016.
  42. Lehrner, Johann, et al. “Ambient odor of orange in a dental office reduces anxiety and improves mood in female patients.” Physiology & Behavior 71.1 (2000): 83-86.
  43. Lehrner, Johann, et al. “Ambient odors of orange and lavender reduce anxiety and improve mood in a dental office.” Physiology & Behavior 86.1 (2005): 92-95.
  44. Tiago Costa Goes, Fabrício Dias Antunes, Péricles Barreto Alves, and Flavia Teixeira-Silva. The Journal of Alternative and Complementary Medicine. August 2012, 18(8): 798-804.  doi:10.1089/acm.2011.0551.
  45. Faturi, Claudia Brito, José Roberto Leite, Péricles Barreto Alves, Adriane Conte Canton, and Flavia Teixeira-Silva. “Anxiolytic-like effect of sweet orange aroma in Wistar rats.” Progress in Neuro-Psychopharmacology & Biological Psychiatry 34.4 (2010): 605-609.
  46. Posadzki, Paul, Amani Alotaibi, and Edzard Ernst. “Adverse effects of aromatherapy: A systematic review of case reports and case series.” The International Journal of Risk & Safety in Medicine 24.3 (2012): 147-161.
  47. Tiran, Denise, and Sue Mack. Clinical aromatherapy for pregnancy and childbirth. Elsevier Health Sciences, 2000.
  48. Hollyer, Taras, et al. “The use of CAM by women suffering from nausea and vomiting during pregnancy.” BMC Complementary and Alternative Medicine 2.1 (2002): 1.
  49. Watt, Martin, Plant Aromatics, In-depth referenced reports and quick reference charts covering skin irritation, photosensitization, toxicity and other safety issues Appalachian Valley Natural Products, (2001).
  50. Johns, Timothy, and Lindi Sibeko. “Pregnancy outcomes in women using herbal therapies.” Birth Defects Research Part B 68.6 (2003): 501-504.
  52. Bessac, Bret F., and Sven-Eric Jordt. “Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.” Physiology 23.6 (2008): 360-370.
  53. Mihara, Satoru, and Takayuki Shibamoto. “The role of flavor and fragrance chemicals in TRPA1 (transient receptor potential cation channel, member A1) activity associated with allergies.” Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology 11.1 (2015).
  54. Wise, Paul M., Paul A.S. Breslin, and Pamela Dalton. “Sweet taste and menthol increase cough reflex thresholds.” Pulmonary Pharmacology and Therapeutics 25.3 (2012): 236-241.
  55. Ueno-Iio, Tomoe, et al. “Lavender essential oil inhalation suppresses allergic airway inflammation and mucous cell hyperplasia in a murine model of asthma.” Life sciences 108.2 (2014): 109-115.
  56. The implementation of aromatherapy into the pediatric oncology setting: an evidenced based initiative, unpublished 3 month pilot study, St Jude’s Children Hospital, Soothing Scents Medical Studies
  57. Melis, K., A. Bochner, and G. Janssens. “Accidental nasal eucalyptol and menthol instillation.” European journal of pediatrics 148.8 (1989): 786-787.
  58. Reichling, Juergen, et al. “Essential oils of aromatic plants with antibacterial, antifungal, antiviral, and cytotoxic properties–an overview.” Forschende Komplementärmedizin/Research in Complementary Medicine 16.2 (2009): 79-90.
  59. Toski, J. A., D. R. Bacon, and R. K. Calverley. “The history of anesthesiology.” Clinical Anesthesia. 4th ed. Philadelphia: Lippincott williams & wilkins (2001): 3




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